Researchers Use Stem Cells to Grow Bone

Researchers at the University of Twente in the Netherlands have found an effective way to stimulate human stem cells to make bone. This breakthrough is important because it allows for the development of new methods to repair bone tissue by using cell material from the patient undergoing treatment.

The key to the development of bone tissue from stem cells is the activation of the enzyme protein kinase A (referred to as PKA). PKA is in charge of many cell processes, such as the regulation of sugar, fats, and glycogen metabolism. PKA is activated by cyclic AMP (cAMP), a nucleotide derived from ATP. The addition of cAMP encourages the maturation of stem cells into bone cells.

This research, led by Dr. Jan de Boer, was conducted at the Tissue Regeneration Department of the University of Twentes Institute for Biomechanical Technology. The researchers worked together with scientists at University Medical Center Utrecht and Erasmus Medical Center in Rotterdam.

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